Glucosamine metabolism of hemolytic streptococcus

Glucosamine Metabolism

Recent studies in this laboratory, concerned with hexosamine metabolism, required Gm-6-P,’ Galm-BP, and their respective N-acetyl derivatives. Several methods are available for the preparation of Cm-6-P, but there appears to be no previous report of Calm-6-P, although an acid-stable Galm-P has been isolated from cartilage (4). Earlier reports indicated that hexokinase and ATP would phosphorylat...

Glucosamine metabolism. V. Enzymatic synthesis of glucosamine 6-phosphate.

Studies in viva on the biosynthesis of n-glucosamine, with the use of specifically labeled glucose in the rat (1,2) and in group A streptococci (3-5) showed that the glucose carbon chain was preserved during its conversion to the hexosamine. Leloir and Cardini (6, 7) noted that extracts obtained from Neurospora crassa converted glutamine and hexose phosphate to glutamic acid and a product tenta...

1 1 2 Uptake and Metabolism of N - Acetylglucosamine and 3 Glucosamine by Streptococcus Mutans

Uptake and metabolism of N-acetylglucosamine and glucosamine by Streptococcus mutans.

Glucosamine and N-acetylglucosamine are among the most abundant sugars on the planet, and their introduction into the oral cavity via the diet and host secretions, and through bacterial biosynthesis, provides oral biofilm bacteria with a source of carbon, nitrogen, and energy. In this study, we demonstrated that the dental caries pathogen Streptococcus mutans possesses an inducible system for t...

Streptococcus pneumoniae infection and hemolytic uremic syndrome.

Sr. Director: Recently it has published in Nefrologia a case of haemolytic uremic syndrome associated to pneumococcal infection (SP-HUS) in a 2-year-6-month old boy with pneumonia, that required veno-venous hemodiafiltration / hemofiltration during ten days. SP-HUS is an uncommon disease whose incidence, following invasive pneumococcal infection, is estimated at 0.4-0.6 %. Its mortality rate is...